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The unique geographic features of Taiwan attribute to the rich of indigenous and endemic plant species in Taiwan. These plants serve as resourceful bank for biologically active phytochemicals.

TIPDB is a structured and searchable database of Anti-Cancer, Anti-Platelet, and Anti-Tuberculosis phytochemicals from indigenous plants in Taiwan. The chemical structures are also curated in the database that provides a great opportunity to develop quantitative structure-activity relationship models for the high-throughput screening of potential anti-cancer, anti-platelet, and anti-tuberculosis drugs.

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  Users can browse plants using the tree menu in the left panel.


To browse a plant, please follow the taxonomy classification.
(a) Order
(b) Family
(c) Genus
(d) Species

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Search funcitons are available in the left panel.


Users can search by either:
(a) part of a plant
(b) class of a chemical
(c) botanical name of a plant
(d) chemical name
(e) TIPdb ID
(f) activity

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Once users have done their search or browsing, results will appear in the right panel as shown in the following figure.
This is an example result of Myriactis humilis. A total of 12 chemicals are available in TIPdb.
(a) The information stored in TIPdb includes botanical name, part, chemical class, chemical and citation. By clicking a specific column head, data will be sorted according to the selected column.
(b) Users can choose how many records in a page.
(c) The chemical name is clickable for detailed activity information.
(d) If an article is available at PubMed database, its PMID will be shown in the end of citation with a hyperlink to PubMed database.

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By clicking a chemical name, activity and strucute information will appear in the bottom panel as shown in the following figures of cytotoxic, anti-platelet and anti-tuberculosis activities.
This figure shows an example record with cytotoxic activity.
(a) 3D structure is represented by Jmol that can be interactively operated.
(b) 2D structure is also available as a image file.
(c) A sortable data table consisting of activity data

This figure shows an example record with anti-platlet activity.
(a) 3D structure is represented by Jmol that can be interactively operated.
(b) 2D structure is also available as a image file.
(c) A sortable data table consisting of activity data
This figure shows an example record with anti-tuberculosis activity.
(a) 3D structure is represented by Jmol that can be interactively operated.
(b) 2D structure is also available as a image file.
(c) A sortable data table consisting of activity data
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Major publications:

Chun-Wei Tung*, Ying-Chi Lin, Hsun-Shuo Chang, Chia-Chi Wang, Ih-Sheng Chen, Jhao-Liang Jheng and Jih-Heng Li (2014) TIPdb-3D: the three-dimensional structure database of phytochemicals from Taiwan indigenous plants, Database: The Journal of Biological Databases and Curation, 2014, bau055.

Ying-Chi Lin, Chia-Chi Wang, Ih-Sheng Chen, Jhao-Liang Jheng, Jih-Heng Li and Chun-Wei Tung* (2013) TIPdb: A Database of Anticancer, Antiplatelet, and Antituberculosis Phytochemicals from Indigenous Plants in Taiwan, The Scientific World Journal, 2013, 736386. [pdf]

Related publications:

Chun-Wei Tung* (2014) Public databases of plant natural products for computational drug discovery, Current Computer-Aided Drug Design, accepted.

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